Endocrine Abstracts

Introduction: RAMPs (receptor activity-modifying proteins) are single-pass transmembrane accessory proteins required for appropriate signalling of the G-protein coupled receptors; CRLR (Calcitonin receptor like receptor) and CTR (Calcitonin receptor). There are three forms of human RAMPs known as, RAMP1, 2 and 3. RAMP3 heterodimerises with CRLR or CTR to form a high affinity receptor for the peptide hormones adrenomedullin and amylin, respectively. However, the exact mechanism...

Background and AimIt is known that the variability of testosterone concentrations is predictive of both truncal and peripheral obesity in healthy men. The aim of this study was to establish the nature of the relationship between testosterone and fat mass in young male cancer survivors compared with healthy controls.Subjects176 male cancer survivors (mean age 37.3 years SD 5.8) who previously received gonadoto...

ObjectivesRemoval of fat results in compensatory weight gain in animals. The objective of this study was to examine changes in weight and fat mass in patients who underwent lipectomy at abdominoplasty and bilateral breast reduction.MethodsIn a retrospective analysis, weight changes in 16 patients who had abdominoplasty and 17 patients who received bilateral breast reduction surgery were compared with 16 patie...

Rationale, aims and objectivesThe GHRH/Arginine and Short Synacthen Tests (SST) have been validated as safer alternatives to the Insulin Tolerance Test for the assessment of the growth hormone reserve and Hypothalamic-Pituitary-Adrenal axis integrity, respectively. However, these two tests are performed separately. The objective of this study was to see whether the synacthen and GHRH/Arginine tests could be combined to save time, blood samples and minimi...

Background: Men who receive gonadotoxic treatment for cancer may be at risk of hypogonadism. The extent of this risk is unknown. Severe hypogonadism is associated with fatigue, sexual dysfunction, reduced muscle mass and obesity. Diagnosing mild or moderate hypogonadism is difficult and requires evaluation.Aim: The aim of this study was to identify hypogonadism in young male survivors of cancer.Subjects and Methods: The study was a...

Background: Quality of life (QoL) has been variously reported as normal or impaired in congenital adrenal hyperplasia (CAH) adults. We found impaired QoL in UK CAH adults (Arlt et al. Journal of Clinical Endocrinology and Metabolism 2010 95 5110–5121) and now report the relationship between QoL (SF-36) and health outcomes in these patients.Methods: Cross-sectional analysis of 151 CAH adults with 21-hydroxylase defi...

Background: A basic tenet for hormone replacement is to replicate physiology but this is rarely if ever achieved. The adrenal glucocorticoid, cortisol, has a distinct circadian rhythm regulated by the brain’s central pacemaker. Loss of the cortisol circadian rhythm is associated with metabolic abnormalities, depression, fatigue and a poor health-related quality of life. Based on pharmacokinetic modelling we have developed a modified-release hydrocortisone (MR-HC) and test...